research field 연구분야


Scripps Korea Antibody Institute
research field - SKAI
새로운 10년, 지역산업과 동반성장하는
항체 사이언스의 선도 연구소로 거듭나겠습니다.


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Title Journal Numbers Year
Novel Antibodies Targeting MUC1-C Showed Anti-Metastasis and Growth-Inhibitory Effects on Human Breast Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms21093258. 2020
BLI-based Functional assay in phage display benefits the development of a PD-L1-targeting therapeutic antibody Viruses doi: 10.3390/v12060684 2020
A Novel Anti-PD-L1 Antibody Exhibits Antitumor Effects on Multiple Myeloma in Murine Models via Antibody-Dependent Cellular Cytotoxicity Journal of Immunology DOI: 10.4062/biomolther.2020.131 2020
Targeting poor proteasomal function with radioiodine eliminates CT26 colon cancer stem cells resistant to bortezomib therapy Scientific Reports DOI: 10.1038/s41598-020-71366-3 2020
89Zr Labeled Anti-PD-L1 Antibody PET Monitors Gemcitabine Therapy-Induced Modulation of Tumor PD-L1 Expression Journal of Nuclear Medicine DOI: 10.2967 2020
Inactivated influenza vaccine formulated with single-stranded RNA-based adjuvant confers mucosal immunity and cross-protection against influenza virus infection Vaccine DOI: 10.1016 2020
Nanoformulated Sing-stranded RNA-based Adjuvant with a Coordinative Amphiphile as an Effective Stabilizer to induce a Humoral Immune Response by Activation of Antigen-presenting Cells Angew Chem Int Ed Engl doi: 10.1002/anie.202002979 2020
Activity-expression profiling of glucose-6-phosphate dehydrogenase in tissues of normal and diabetic mice Biochemical and Biophysical Research Communications pii: S0006-291X(20)30250-3. 2020
Perivascular Stem Cells Suppress Inflammasome Activation during Inflammatory Responses in Macrophages International Journal of Stem Cells 12(3):419-429. 2019
Antibody-Based Targeting of Cell Surface GRP94 Specifically Inhibits Cetuximab-Resistant Colorectal Cancer Growth Biomolecules 9(11). pii: E681. 2019
Development of a Theranostic Convergence Bioradiopharmaceutical for Immuno-PET Based Radioimmunotherapy of L1CAM in Cholangiocarcinoma Model Clinical Cancer Research 25(20):6148-6159. 2019
Magnetic Resonance Colonography Enables the Efficacy Assessment of Immune Checkpoint Inhibitors in an Orthotopic Colorectal Cancer Mouse Model Translational Oncology 12(9):1264-1270. 2019
Ultrasensitive NIR-SERRS Probes with Multiplexed Ratiometric Quantification for In Vivo Antibody Leads Validation Advanced Healthcare Materials 7(4). doi: 10.1002/adhm.201700870. 2018
Generation of a human monoclonal antibody to cross-reactive material 197 (CRM₁₉₇) and development of a sandwich ELISA for CRM₁₉₇ conjugate vaccines Journal of Microbiology and Biotechnology 28(12):2113-2120. 2018
Generation and Characterization of a Neutralizing Human Monoclonal Antibody to Hepatitis B Virus PreS1 from a Phage-Displayed Human Synthetic Fab Library Journal of Microbiology and Biotechnology doi: 10.4014/jmb.1804.03056. 2018
Emerging Roles of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Immunological Disorders and Cancer International journal of molecular sciences 19(4). pii: E1057. 2018
Inhibition of VEGF-dependent angiogenesis and tumor angiogenesis by an optimized antibody targeting CLEC14a Molecular Oncology 12(3):356-372. 2018
Generation, Diversity Determination, and Application to Antibody Selection of a Human Naïve Fab Library Molecules and Cells 40(9):655-66. 2017
CLEC14a-HSP70-1A interaction regulates HSP70-1A-induced angiogenesis Scientific Reprots 7(1):10666 2017
A Review of Anti-Angiogenic Targets for Monoclonal Antibody Cancer Therapy International Journal of Molecular Sciences 18(8). pii: E1786. 2017
A human antibody that binds to the sixth Ig-like domain of VCAM-1 blocks lung cancer cell migration in vitro International Journal of Molecular Sciences 18(3). pii: E566. 2017
Ig-like Domain 6 of VCAM-1 is a Potential Therapeutic Target in TNFα-induced Angiogenesis Experimental and Molecular Medicine 49(2):e294. 2017
Adaptor Protein 2 (AP-2) complex is essential for functional axogenesis in hippocampal neurons axogenesis in hippocampal neurons Scientific Reprots 7:41620. 2017
Development of a sandwich enzyme-linked immunosorbent assay for the detection of CD44v3 using exon v3- and v6-specific monoclonal antibody pairs Journal of Immunological Methods 436:22-8. 2016
Therapeutic Targeting of Tetraspanin8 in Epithelial Ovarian Cancer Invasion and Metastasis Oncogene 35(34):4540-8. 2016
Heat shock protein 70-1A is a novel angiogenic regulator Biochemical and Biophysical Research Communications 469(2):222-8. 2016
Generation of a human antibody that inhibits TSPAN8-mediated invasion of metastatic colorectal cancer cells Biochemical and Biophysical Research Communications 468(4):774-80. 2015
Extension of the in vivo half-life of endostatin and its improved anti-tumor activities upon fusion to a humanized antibody against tumor-associated glycoprotein 72 in a mouse model of human colorectal carcinoma Oncotarget 6(9):7182-94. 2015
Human antibodies targeting the C-type lectin domain of the tumor endothelial cell marker clec14a regulate angiogenic properties in vitro Oncogene 32(48):5449-57. 2013
Afamin stimulates osteoclastogenesis and bone resorptio via Gi-coupled receptor and Ca2+/calmodulin-dependent protein kinase (CaMK) pathways Journal of Endocrinological Investigation 36(10):876-82. 2013
Converting stem cells to dendritic cells by agonist antibodies from unbiased morphogenic selections Proceedings of The National Academy of Sciences of The United States of America 110(37):14966-71. 2013
Engineering hydrophobic protein-carbohydrate interactions to fine-tune monoclonal antibodies Journal of the American Chemical Society 135(26):9723-32. 2013
Enzymatic production and expression of shRNAmir30 from cDNAs Genes & Genomics 35(3):395-403. 2013
Selecting Agonists from Single Cells Infected with Combinatorial Antibody Libraries Chemistry & Biology 20(5):734-41. 2013
Autocrine signaling based selection of combinatorial antibodies that transdifferentiate human stem cells Proceedings of The National Academy of Sciences of The United States of America 110(20):8099-104. 2013
Engineering Cell Surfaces for Orthogonal Selectability Anagewandte Chemie-International Edition 52(1):336-40. 2013
An Antibody to the Sixth Ig-like Domain of VCAM-1 Inhibits Leukocyte Transendothelial Migration without Affecting Adhesion Journal of Immunology 189(9):4592-601. 2012
Chemical and Structural Analysis of an Antibody Folding Intermediate Trapped during Glycan Biosynthesis Journal of the American Chemical Society 134(42):17554-63. 2012
Gremlin-1 Induces BMP-Independent Tumor Cell Proliferation, Migration, and Invasion PLoS One 7(4):e35100. 2012
Cholesterol Secosterol Aldehydes Induce Amyloidogenesis and Dysfunction of Wild-Type Tumor Protein p53 Chemistry & Biology 18(7):920-7. 2011
Aurintricarboxylic acid inhibits the nuclear factor-kB-dependent expression of intercellular cell adhesion molecule-1 and endothelial cell selectin on activated human endothelial cells Blood Coagulation & Fibrinolysis 22(2):132-9. 2011
Spatially addressed combinatorial protein libraries for recombinant antibody discovery and optimization Nature Biotechnology 28(11):1195-202. 2010