ⓑ연구성과

본문 바로가기

주요사업 연구사업 소개 ⓑ연구성과

ⓑ연구성과

연구성과
미충족 의료 수요 해결에 기여할 수 있는 핵심원천기술의 개발 및 이를 통한 혁신항체치료제 개발
Title Journal Numbers Year
Generation and Characterization of a Neutralizing Human Monoclonal
Antibody to Hepatitis B Virus PreS1 from a Phage-Displayed Human Synthetic Fab Library
Journal of Microbiology and Biotechnology doi: 10.4014. 2018
Emerging Roles of Vascular Cell Adhesion Molecule-1 (VCAM-1)
in Immunological Disorders and Cancer
International journal of molecular sciences 19(4). pii: E1057. 2018
Inhibition of VEGF-dependent angiogenesis and tumor
angiogenesis by an optimized antibody targeting CLEC14a
Molecular Oncology 12(3):356-372. 2018
Generation, Diversity Determination, and Application to
Antibody Selection of a Human Naïve Fab Library
Molecules and Cells 40(9):655-66. 2017
CLEC14a-HSP70-1A interaction regulates HSP70-1A-induced
angiogenesis
Scientific Reprots 7(1):10666 2017
A Review of Anti-Angiogenic Targets for Monoclonal
Antibody Cancer Therapy
International Journal of Molecular Sciences 18(8). pii: E1786. 2017
A human antibody that binds to the sixth Ig-like domain of
VCAM-1 blocks lung cancer cell migration in vitro
International Journal of Molecular Sciences 18(3). pii: E566. 2017
Ig-like Domain 6 of VCAM-1 is a Potential Therapeutic Target
in TNFα-induced Angiogenesis
Experimental and Molecular Medicine 49(2):e294. 2017
Adaptor Protein 2 (AP-2) complex is essential for functional
axogenesis in hippocampal neurons
Scientific Reprots 7:41620. 2017
Development of a sandwich enzyme-linked immunosorbent
assay for the detection of CD44v3 using exon v3- and
v6-specific monoclonal antibody pairs
Journal of Immunological Methods 436:22-8. 2016
Therapeutic Targeting of Tetraspanin8 in
Epithelial Ovarian Cancer Invasion and Metastasis
Oncogene 35(34):4540-8. 2016
Heat shock protein 70-1A is a novel angiogenic regulator Biochemical and Biophysical Research
Communications
469(2):222-8. 2016
Generation of a human antibody that inhibits
TSPAN8-mediated invasion of metastatic colorectal
cancer cells
Biochemical and Biophysical Research
Communications
468(4):774-80. 2015
Extension of the in vivo half-life of endostatin and its
improved anti-tumor activities upon fusion to a humanized
antibody against tumor-associated glycoprotein 72 in a
mouse model of human colorectal carcinoma
Oncotarget 6(9):7182-94. 2015
Human antibodies targeting the C-type lectin domain of the
tumor endothelial cell marker clec14a regulate
angiogenic properties in vitro
Oncogene 32(48):5449-57. 2013
Afamin stimulates osteoclastogenesis and bone resorptio
via Gi-coupled receptor and Ca2+/calmodulin-dependent
protein kinase (CaMK) pathways
Journal of Endocrinological Investigation 36(10):876-82. 2013
Converting stem cells to dendritic cells by agonist
antibodies from unbiased morphogenic selections
Proceedings of The National Academy
of Sciences of The United States
of America
110(37):14966-71. 2013
Engineering hydrophobic protein-carbohydrate interactions
to fine-tune monoclonal antibodies
Journal of the American Chemical Society 135(26):9723-32. 2013
Enzymatic production and expression of shRNAmir30
from cDNAs
Genes & Genomics 35(3):395-403. 2013
Selecting Agonists from Single Cells Infected with
Combinatorial Antibody Libraries
Chemistry & Biology 20(5):734-41. 2013
Autocrine signaling based selection of combinatorial
antibodies that transdifferentiate human stem cells
Proceedings of The National Academy
of Sciences of The United States
of America
110(20):8099-104. 2013
Engineering Cell Surfaces for Orthogonal Selectability Anagewandte Chemie-International Edition 52(1):336-40. 2013
An Antibody to the Sixth Ig-like Domain of VCAM-1
Inhibits Leukocyte Transendothelial Migration without
Affecting Adhesion
Journal of Immunology 189(9):4592-601. 2012
Chemical and Structural Analysis of an Antibody Folding
Intermediate Trapped during Glycan Biosynthesis
Journal of the American Chemical Society 134(42):17554-63. 2012
Gremlin-1 Induces BMP-Independent Tumor Cell
Proliferation, Migration, and Invasion
PLoS One 7(4):e35100. 2012
Cholesterol Secosterol Aldehydes Induce Amyloidogenesis
and Dysfunction of Wild-Type Tumor Protein p53
Chemistry & Biology 18(7):920-7. 2011
Aurintricarboxylic acid inhibits the nuclear
factor-kB-dependent expression of intercellular cell
adhesion molecule-1 and endothelial cell selectin on
activated human endothelial cells
Blood Coagulation & Fibrinolysis 22(2):132-9. 2011
Spatially addressed combinatorial protein libraries for
recombinant antibody discovery and optimization
Nature Biotechnology 28(11):1195-202. 2010